365足球滚球
当前位置:首页 > 研究组动态

孔磊等撰写的论文被Anal. Chem.正式接收发表

发布时间:2019-04-17
       恭喜孔磊等撰写的论文“Micromotor-Assisted Human Serum Glucose Biosensing被美国化学学会旗下分析化学领域top期刊Anal. Chem.(中科院一区,影响因子6.042)正式接收发表(2019, DOI: 10.1021/acs.analchem.8b05464)! 在该论文中,新加坡南洋理工大学Martin Pumera教授等和我们合作发现,使用具有自更新表面的Mg/Pt双面神微米马达能够增强电化学检测人体血清中葡萄糖的传感信号和灵敏度。葡萄糖的电化学检测是基于第二代葡萄糖生物传感系统,其中Mg/Pt双面神微米马达在人体血清中产生的氢气泡及其形成的反冲作用驱使Mg/Pt双面神微米马达快速运动能够极大地提高检测液中的传质,加速葡萄糖氧化酶对葡萄糖以及二茂铁甲醇在电极上的氧化,从而增强葡萄糖的电化学检测信号。所获得的时间电流测量数据表明,Mg/Pt Janus微马达在人血清中葡萄糖浓度为毫摩尔时,在增强电流响应方面具有协同作用,电流信号随着微米马达数量的增加而增加。此外,通过建立电流信号与葡萄糖浓度之间的线性关系,发现运动的Mg/Pt双面神微米马达能够提高人体血清中葡萄糖的最低检测限度。微米马达增强人体血清中血糖的检测为未来微纳米机器在生物医药和医疗诊断设备中的应用奠定了基础。


     原文详细摘要如下:Artificial self-propelled micromachines have shown great promise in biomedical sciences. In this work, we use Mg/Pt Janus micromotors with self-rejuvenating surfaces to enhance the electrochemical sensing performance and sensitivity toward glucose in human serum. The detection of glucose is based on the glucose oxidase enzyme and ferrocenemethanol shuttle system, where mass transfer was dramatically enhanced by the rapid motion of Mg/Pt Janus micromotors. The obtained chronoamperometric data show that Mg/Pt Janus micromotors play a synergistic role in enhancing the current response at millimolar concentrations of glucose in human serum. The current signals increased with the corresponding increase in amount of micromotors introduced. Furthermore, a linear relationship between current signal and glucose concentration was established, while the limit of detection improved when mobile Mg/Pt Janus micromachines were used. Glucose detection enhanced by micromachines may pave the way for their future applications in biomedicine and medical diagnostic devices.


附件下载:   

Tel: 86-27-87218832

Fax: 86-27-87879466

E-mail: guanjg@whut.edu.cn