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罗明、姜玉周等撰写的论文被Chem. Asian J.正式接收发表

发布时间:2019-04-20
     祝贺罗明、姜玉周等撰写的论文Surface Charge-Reversible Tubular Micromotors for Extraction of Nucleic Acids in MicrosystemsWiley旗下期刊Chem. Asian J.正式接收发表(2019,  http://dx.doi.org/10.1002/asia.201900427)。在该论文中,我们利用阳离子聚合物PEI修饰的管状微米马达发展了一种微体系中高效萃取核酸的方法。利用管状微米马达在酸性过氧化氢溶液中的自主运动特性和静电吸引作用能从临床生物样品中高效选择性吸附核酸,然后还能利用外加磁场操控表面吸附核酸的马达运动方向,自主运动到碱性水溶液中释放捕获的核酸,完成核酸的萃取提纯任务,而且整个过程无需外界能量输入,也无需机械泵协助。本文发展的这种表面电性可调的管状微米马达可为微体系中核酸的萃取提供一种新方法,促进微纳米马达在生物医药领域的实际应用。 
     原文详细摘要如下:Extraction of nucleic acids in microsystems is of significance for biomedical applications, but the current extraction methods generally require sophisticated microchannels and external equipment, hindering their practical applications. In this work, we have demonstrated a simple, versatile and efficient approach to extract nucleic acids in microsystems by developing cationic branched polyethyleneimine (PEI)-functionalized tubular micromotors. The as-developed tubular micromotors are fabricated by a two-step process combining the template-assisted electrodeposition and carbodiimide chemistry, and contain an inner catalytic Pt layer, a middle magnetic Ni layer and an outer cationic PEI layer. They exhibit autonomous bubble-propelled motion in aqueous hydrogen peroxide solutions, which can be guided by an external magnetic field, and can reversibly modulate the surface charges by changing the pH value of the solution. Consequently, the as-developed tubular micromotors can selectively absorb nucleic acids from acidic solutions and desorb them into alkaline solutions, leading to extract nucleic acids in high efficiency without external stirring. Furthermore, they can be operated in a microchannel chip without the aid of pumping system. Our results indicate that this PEI-functionalized tubular micromotor platform provides a novel, simple and versatile microsystem nucleic acid extraction technology, holding considerable promises for important practical applications.

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